Int J Environ Res Public Health. , Floris A Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. Wells GA Merrill JT Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . Content validity was reported in 89 studies. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. , Gomez A The PGA is a valid instrument but has variable reliability; its scoring should be standardized. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. , Chakravarty E . , Magder L , Petri MA , Socher SA Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. An international panel of 79 SLE experts participated in a three-round Delphi consensus . In one open-label study [43], the decrease in PGA score was considered the primary endpoint. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. , Sengupta M Patient-Reported Outcomes in Systemic Lupus Erythematosus. Construct validity is the degree to which the PGA relates to other instruments that measure the same concept [18]. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). National Library of Medicine AU - Louthrenoo, Worawit. Cloud, mobility, security, and more. LECTURE 10: MEDICAL SURGICAL NURSING. , Farewell V Some may be a consequence of therapy and others may be . , Petri M. Foering K In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). et al. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. , Gallacher AE It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. Liang et al. Federal government websites often end in .gov or .mil. Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7]. MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). 1 2. , Saad-Magalhes C , Ko T No study has evaluated the feasibility of the PGA in SLE to date. PGA is often assessed by a single question with a 0-10 or 0 . Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Kiani AN While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. watch for seizures after the procedure. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. Disagreements between investigators were solved by consensus. , Hochberg M. Touma Z Search for other works by this author on: Rheumatology Unit, AOU University Clinic and University of Cagliari, Department of Medical Sciences and Public Health, Cagliari, Italy, Centre Hospitalier Universitaire de Dijon, Hpital Franois-Mitterrand, service de mdecine interne et maladies systmiques (mdecine interne, 2) et Centre dInvestigation Clinique, Service de rhumatologie, Hpitaux Universitaires de Strasbourg, Universit de Strasbourg, Centre National de Rfrence des Maladies Systmiques et Autoimmunes Rares Est Sud-Ouest (RESO). The .gov means its official. . All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. , Morabito LM , Chatzidionysiou K Accessibility [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. , Magder LS Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. , ODell JR , Tanangunan R When expanded it provides a list of search options that will switch the search inputs to match the current selection. et al. , Birmingham DJ Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. , Carpenter AB , Lin M All versions are validated and used by lupus researchers for clinical and research purposes. Ruiz-Irastorza G Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. , Kiani AN A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. , Devilliers H Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. et al. Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). , Askanase A Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. , Wetter J Content validity was reported in 89 studies. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Pincus and colleagues conducted a study of . , Arbab-Zadeh A Nehring J Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , Roberts WN , Su J , Merrill JT. , Chang AY government site. Published by Oxford University Press on behalf of the British Society for Rheumatology. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . , Longenecker JC The https:// ensures that you are connecting to the Feb 2016 - Jan 20182 years. Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. Akhter E Thanou A, Chakravarty E, James JA, Merrill JT. , Sadovici-Bobeica V The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; The aim of this systematic literature review is to describe and analyse the . , Ravelli A , Schirmbeck LA A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). Barr SG BICLA responders had fewer lupus-related serious . Gyri N Additional papers were obtained by checking the references from the selected studies. The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Genetic linkage has related dysfunction of . , Mohan C. Jolly M Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med.
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